PIP2—the Master Key

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PIP2—the Master Key

The function of inwardly rectifying K+ (Kir) channels is highly diverse and therefore is tightly regulated by various environmental factors. In their article in this issue of Neuron, Rapedius et al. recognize a conserved structural mechanism for Kir channels gating by both pH and PIP2. In light of these findings and accumulated knowledge, PIP2 is suggested to have a common coregulatory role in ...

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ژورنال

عنوان ژورنال: Neuron

سال: 2007

ISSN: 0896-6273

DOI: 10.1016/j.neuron.2007.08.001